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Our science
Where genomics and clinical medicine meet
OpenDNA combines cutting-edge polygenic science with clinical data integration to deliver risk insights that are more accurate, more personalized, and more actionable than any single source of data alone.Polygenic science plus clinical data for more accurate insights.
01
Polygenic Risk Scores (PRS)
Unlike single-gene tests, our polygenic models analyze over one million genetic variants or SNPs (Single Nucleotide Polymorphisms) simultaneously. This captures the cumulative effect of your entire genome on condition risk, rather than the contribution of a single gene.We analyze over one million genetic variants (SNPs) at once.
For coronary artery disease, a model combining a polygenic score with clinical data identified more at-risk adults than the standard clinical risk calculator. Read the study →
02
Clinical data integration
Genetic signals become far more powerful when combined with clinical measurements. Our models integrate your genetic profile with clinical and lifestyle factors — delivering a complete, personalized risk picture based on both your genetic and clinical profile.We combine your genetics with clinical and lifestyle factors.
03
Peer-reviewed research
Our coronary artery disease model is built on peer-reviewed research and validated in a large population cohort. Each risk score is calibrated to reflect your risk relative to the general population, giving you a meaningful benchmark for proactive action.Peer-reviewed; our coronary artery disease model is validated in a large cohort.
Explore the research behind our modelsOur research
04
Physician-reviewed insights
Every report is reviewed and signed by a board-certified physician licensed in your state. Our clinical team ensures that insights are medically accurate, contextually relevant, and actionable — not just a data printout.Every report is signed by a board-certified physician licensed in your state.
The evidence
What the published studies show
BMC Medical Genomics, 2025
Coronary artery disease risk prediction
A model combining a polygenic risk score with clinical factors identified more at-risk adults than the standard clinical risk calculator.
Read the study →Frontiers in Genetics, 2025
Polygenic scores and physician decision-making
In a clinical study of patients, polygenic results influenced physicians' management decisions, most often patient education and monitoring.
Read the study →Both studies were funded by OpenDNA, and some of the authors are OpenDNA employees.
"Genetics alone isn't enough. The future of preventive medicine combines your DNA with who you are clinically — and what you can change.""Genetics alone isn't enough. Prevention combines your DNA with who you are clinically."
OpenDNA Science Team